However, adjunctive therapies sustaining inflammatory support enabled effective clearance. Neutrophil densities declined further during treatment in response to receding Salmonella loads, resulting in insufficient support for Salmonella clearance from the white pulp and eradication failure. Instead, antimicrobial clearance required support of Salmonella-killing neutrophils and monocytes, and the density of such cells was lower in the white pulp than in other spleen compartments containing higher Salmonella loads. Previous models could not explain these findings: drug exposure was adequate, Salmonella continued to replicate, and host stresses induced only limited Salmonella drug tolerance. Chemotherapy cleared >99.5% of the Salmonella but was inefficient against a small Salmonella subset in the white pulp. Here, we localized and characterized rare surviving Salmonella in mouse spleen using high-resolution whole-organ tomography. In vitro studies suggest various mechanisms of antibiotic persistence, but their in vivo relevance remains unclear because of the difficulty of studying scarce pathogen survivors in complex host tissues. Persisting pathogens can subsequently cause relapsing diseases. The representation can be seen from the consumption patterns, interactions, and self-expression of IRS' members.Antimicrobial chemotherapy can fail to eradicate the pathogen, even in the absence of antimicrobial resistance. This study shows that social class represented by amateur runners in IRS community is included in the new petite bourgeoisie. The method conducted is qualitative method by conducting interviews with key informants and observations. Researchers applied the theory of Distinction by Pierre Bourdieau and consumerism by Michael Featherstone. The purpose of this study is to see the representation of a class that emerged in IRS. Over time, amateur runners who are members of the IRS created a social class that is different from other sports community. With its regular events such as Sunday Morning Run and Thursday Night Run, IRS has nearly 1,000 members spread across Surabaya. It is called as Indorunners Chapter Surabaya (IRS), which was established in 2012. One of the running communities in Indonesia is Indorunners, which originally established in Jakarta and then spread in various cities in Indonesia, including Surabaya. By the development of running in Indonesia, there were some running communities initiated by individual running activists. During that year, there is at least one or even more running competitions held by the sponsor in a month. This hypes were captured by several sponsors who often hold running competitions. Running in Indonesia has begun to spread since the beginning of 2013, accompanied by a decline in the prestige of cycling at the same time.
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